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PSYART  December 2002, Week 3

PSYART December 2002, Week 3

Subject:

Fear gene

From:

Norman Holland <[log in to unmask]>

Reply-To:

Institute for Psychological Study of the Arts <[log in to unmask]>

Date:

Mon, 16 Dec 2002 17:01:04 -0500

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (89 lines)

kirby farrell wrote:
 >
 > BBC
 > Sunday, 15 December, 2002, 00:00 GMT
 >                      'Fear gene' could unlock
 >                      mental illness
 >
 >                      Genes may hold the key to anxiety
 >                      The discovery of a gene in mice that plays a role in
 >                      learning to be afraid could provide clues to the
 > origins
 >                      of severe mental illness, say researchers.
 >
 >                      Scientists at the Howard Hughes Medical Institute
 >                      believe they have found one of the key elements in
the
 >                      process of "learned fear".
 >
 >                      This is where animals, including humans, learn over
 >                      time that something is a threat or danger, as
opposed
 >                      to the instinctive fear which animals are born with.
 >
 >                      The US team bred two groups of
 >                      mice - one normal, and one lacking a
 >                      gene called GRP - which earlier
 >                      studies suggested might be linked to
 >                      a particular region of the brain called
 >                      the amygdala, which is often
 >                      associated with fear.
 >
 >                      GRP appears to inhibit the
 >                      action of "circuitry" in the
 >                      brain which learns fear.
 >
 >                      The mice were "taught" fear
 >                      by linking a specific noise
 >                      with an electric shock.
 >
 >                      Then their response to the
 >                      tone on its own was
 >                      measured.
 >
 >                      Long freeze
 >
 >                      Those with the GRP gene lacking had a
 >                      greatly-enhanced fear response, "freezing" for much
 >                      longer than the normal mice.
 >
 >                      They were no more sensitive to pain, or increased
 >                      instinctive fear.
 >
 >                      Professor Eric Kandel, a member of the research
team,
 >                      said: "These findings reveal a biological basis for
 > what
 >                      had only been previously inferred from psychological
 >                      studies - that instinctive fear, chronic anxiety, is
 >                      different from acquired fear."
 >
 >                      Anxious for drugs
 >
 >                      In theory, the finding could start to shed light on
the
 >                      origins of anxiety disorders, and perhaps potential
 > ways
 >                      to treat them.
 >
 >                      Professor Kandel said: "Since GRP acts to dampen
fear,
 >                      it might be possible in principle to develop drugs
that
 >                      activate the peptide, representing a completely new
 >                      approach to treating anxiety.
 >
 >                      "And while I don't want to overstate the case, in
 > studies
 >                      of fear learning we could well have a excellent
 >                      beginning for animal models of a severe mental
illness.
 >
 >                      "We already knew quite a lot about the neural
pathways
 >                      in the brain that are involved in fear learning.
 >
 >                      "And now we have a way to understand the genetic and
 >                      biochemical mechanisms underlying those pathways.
 >
 > _________________________________________________________________

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