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Yes, you can use ergm's to do this.  See Pavel Krivitsky's recent paper:

http://www.sciencedirect.com/science/article/pii/S1572312711000086 or
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117581/


On Wed, 9 Apr 2014, Matt Robbins wrote:

> ***** To join INSNA, visit http://www.insna.org ***** Anyone know of a method for conducting significance tests on
> changes over time in network summary statistics (density, transitivity, reciprocity etc.) for a network that is
> changing in size across the observed time points?
> Thanks in advance,
> 
> Matt
> 
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