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Dear all,

this is my first question here!

 

following problem:

 

I have data on a certain complex association network (from monomers 1 ... 8 to complexes of all combinations, such as, 12 ... 13 ... 18 and so on until 12345678, so that I know

 

the structure of the network (255 vertices) the edges of the network the concentrations of the vertices From this data I now wish to infer the preferred route(s) of assembly for those complexes - which should be the rate constants for the edges, such as 1 --> 12 or 145 --> 1458. Does that make sense? Final result should be a set of paths of length 8 starting from (1..8) ending up at (12345678).

 

I have now tried various standalone applications for network creation/analysis as well as R packages. Metabolic flux analysis seemed promising for me, but it turned out that it only works with set external concentrations and assumes steady-state for all metabolites within the network. Which is not the case for me. Do you know of any alternative method?

 

Thanks and best wishes,

Simon

 

 

Simon Prisner

PhD student

Humboldt-Universität zu Berlin / Max-Delbrück-Centrum Berlin

AG Molekulare Biophysik  -  Institut für Biologie, Invalidenstraße 42,  10115 Berlin, Germany

office: 214 --- phone: +49 30 2093 8466

 

email: [log in to unmask]

www: http://www2.hu-berlin.de/biologie/molbp/

 

 

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