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The first paper is overstated, but still interesting

   Barry Wellman

   Step by step, link by link, putting it together--Streisand/Sondheim
        The earth to be spannd, connected by network--Walt Whitman
              It's Always Something--Roseanne Roseannadanna
  _______________________________________________________________________
   NetLab Network                 FRSC                      INSNA Founder
   Distinguished Visiting Scholar   Social Media Lab   Ryerson University
   NETWORKED: The New Social Operating System  Lee Rainie & Barry Wellman
   https://urldefense.proofpoint.com/v2/url?u=http-3A__www.chass.utoronto.ca_-7Ewellman&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=Dr-MIAHw9BQ3XLt2vC4tB17SgbUM78M7fQhQ5okSWhg&e=            https://urldefense.proofpoint.com/v2/url?u=http-3A__amzn.to_zXZg39&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=jnlP-NJqeaKhj9JeZr8wfBcJKekT6jgCdn3oV9D1dJk&e=
              https://urldefense.proofpoint.com/v2/url?u=https-3A__en.wikipedia.org_wiki_Barry-5FWellman&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=ZdgzDS9leXknmIK0x2YjYOquCy_bQ4mGv8iaEVi1BSc&e=
   _______________________________________________________________________


---------- Forwarded message ----------
Date: Mon, 25 Jun 2018 11:04:11 +0000
From: "[utf-8] Complexity Digest" <[log in to unmask]>
Reply-To: [log in to unmask]
To: "[utf-8] Barry" <[log in to unmask]>
Subject: [utf-8] Latest Complexity Digest Posts

Learn about the latest and greatest related to complex systems research. More at https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D263fecaa09-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=_PShINXl-exoeEERWHlFS1OTPQxbvujwyVEoQGdiWEM&e=



Twenty years of network science

    https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D472e5ace01-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=oHhA6kvJVhXvOg2-8Ji0XLskXkzpV24IzTqm_YBu6Y0&e=

The idea that everyone in the world is connected to everyone else by just six degrees of separation was explained by the ˙˙small-world˙˙ network model 20 years ago. What seemed to be a niche finding turned out to have huge consequences.

Source: www.nature.com (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D1c5f9e1ad0-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=bLPCiwEfJTgAoUF4bOChrGMWVLQe0oGSe6-jjRL5e5c&e=)



Predicting perturbation patterns from the topology of biological networks

    High-throughput technologies, offering unprecedented wealth of quantitative data underlying the makeup of living systems, are changing biology. Notably, the systematic mapping of the relationships between biochemical entities has fueled the rapid development of network biology, offering a suitable framework to describe disease phenotypes and predict potential drug targets. Yet, our ability to develop accurate dynamical models remains limited, due in part to the limited knowledge of the kinetic parameters underlying these interactions. Here, we explore the degree to which we can make reasonably accurate predictions in the absence of the kinetic parameters. We find that simple dynamically agnostic models are sufficient to recover the strength and sign of the biochemical perturbation patterns observed in 87 biological models for which the underlying kinetics is known. Surprisingly, a simple distance-based model achieves 65% accuracy. We show that this predictive power is robust
to topological and kinetic parameters perturbations, and we identify key network properties that can increase up to 80% the recovery rate of the true perturbation patterns. We validate our approach using experimental data on the chemotactic pathway in bacteria, finding that a network model of perturbation spreading predicts with ~80% accuracy the directionality of gene expression and phenotype changes in knock-out and overproduction experiments. These findings show that the steady advances in mapping out the topology of biochemical interaction networks opens avenues for accurate perturbation spread modeling, with direct implications for medicine and drug development.


Predicting perturbation patterns from the topology of biological networks

Marc Santolini, Albert-Laszlo Barabasi
doi: https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3Dcfb581f94b-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=1_9H8tEOaEHbY-GmLv-rmkdDuHfcFurRqwhI7ZAaCfg&e=

Source: www.biorxiv.org (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D7166f13336-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=AoP8suiUYxk_vusFNTxlPdMGgL2sVH6awY3w6JGIgD4&e=)



Misinformation and biases infect social media, both intentionally and accidentally

    Social media are among the primary sources of news in the U.S. (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D30355a1c33-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=U7v6_pL0NotSiBLs8MIjz3MUk2MDb7eP2c6TxCcYlS4&e=) and across the world. Yet users are exposed to content of questionable accuracy, including conspiracy theories (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D4f68b9d61c-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=3z7eC3Og-xnVc5GsBz-hVe7AfyWTmljb3YJmGcz2HYM&e=) , clickbait (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3Da9f3066778-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=vEdT5IMmx88xyp0oAeH48OGXyfxeeUeBZCva7KTKzSs&e=) , hyperpartisan content (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3De4add6f5e5-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=3gcZBO_D70ZX9WlDEGCuUG_XnnGuTvwddsGQZFYoMPM&e=) , pseudo science (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D5608377121-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=t4TShiy5_N-40OjFqEFPUjvIDUNG1tKM595bPygdqjI&e=) and even fabricated ˙˙fake news˙˙ reports (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D910d2d5f29-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=yVcfbWSsugzMgOdn09iKxMluR3RYbhHGnKNpz78oW9c&e=) .

It˙˙s not surprising that there˙˙s so much disinformation published: Spam and online fraud are lucrative for criminals (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D4ac4b69325-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=xUP4LsjUAoxfYE2GTP33L5am_Bskvg9HeLeXvyey9v8&e=) , and government and political propaganda yield both partisan and financial benefits (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D86cad860bb-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=hOscjcLhBrekXLvGBG6kTHkmbp2ZsML2FmvKToETwUk&e=) . But the fact that low-credibility content spreads so quickly and easily (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3Df0c234122e-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=rlLmiSON6yajR42Ti6GgLQxIRVyKPz-JVJx5dZUaeM4&e=) suggests that people and the algorithms behind social media platforms are vulnerable to manipulation.

Source: theconversation.com (https://urldefense.proofpoint.com/v2/url?u=https-3A__unam.us4.list-2Dmanage.com_track_click-3Fu-3D0eb0ac9b4e8565f2967a8304b-26id-3D5d46df817d-26e-3D55e25a0e3e&d=DwIFAw&c=pZJPUDQ3SB9JplYbifm4nt2lEVG5pWx2KikqINpWlZM&r=uXI5O6HThk1ULkPyaT6h2Ws3RKNKSY__GQ4DuS9UHhs&m=0LolwnlsqnCvqWwaflSwbS0kMjnA-87r-tfTsk5PPzA&s=GyZO5gjkjWcjiAHsgf3ZaccHMrTr2z6i-7X9Z5_Dt78&e=)




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